反应详情

温度

0 °C

TFA (30 ml) was added to a cooled solution of N,N′-di(tert-butyloxycarbonyl)-2-[3-(pyrid-2-yl)isoxazol-5-yl]pyrrolidine-1-carboximidamide (Method 39) in DCM (150 ml) at 0° C. The mixture was stirred 0° C. for one hour, allowed to warm to ambient temperature and stirred for a further 18 hours. The volatiles were removed by evaporation and the residue triturated from DCM/ether/hexane. The product was collected by filtration to give the title compound (2.2 g, >100%).

1. temperatureto warm to ambient temperature
2. stirringstirred for a further 18 hours
3. customThe volatiles were removed by evaporation
4. customthe residue triturated from DCM/ether/hexane
5. filtrationThe product was collected by filtration