Hydroxyamine hydrochloride → 1h-Imidazo[4,5-c][1,5]naphthyridine

HRID 2105454노트

반응식

HRID 2105454 반응식
Cl[C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][N:10]=2)[N:5]=[CH:4][C:3]=1[NH-:12].ClC1C2C(=CC=CC=2)[N:17]=[CH:16]C=1[NH-].Cl.NO>>[NH:17]1[C:2]2[C:11]3[N:10]=[CH:9][CH:8]=[CH:7][C:6]=3[N:5]=[CH:4][C:3]=2[N:12]=[CH:16]1

참가 물질

4

반응물 3

HCID 443297Hydroxyamine hydrochlorideHCID 86625942HCID 86625942, 화합물HCID 86625943HCID 86625943, 화합물

생성물 1

HCID 1784207351h-Imidazo[4,5-c][1,5]naphthyridine

실험 절차

In step (7) of Reaction Scheme II, an N-(4-chloro[1,5]naphthyridin-3-yl)amide or N-(4-chloroquinolin-3-yl)amide of Formula XXXII is reacted with a hydroxylamine hydrochloride of Formula R1ONH2.HCl and cyclized to provide a 1H-imidazo[4,5-c][1,5]naphthyridine or a 1H-imidazo[4,5-c]quinoline of Formula XXXIII. The reaction can be carried out using the method described in step (3) of Reaction Scheme I.

후처리

  1. customIn step (7) of Reaction Scheme II

출처 및 근거

ORD 기록
ord-3d95590124734aa587f6d5bd3fa2a929
출처 데이터셋
uspto-grants-2009_08
특허 번호
US07579359B2

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