Methyl acetoacetate → 5-(5-Chloro-2-fluoro-phenyl)-1-((S)-2,2-dimethyl-cyclopropylmethyl)-2-methyl-1H-pyrrole-3-carboxylic acid ((1R,2R)-2-hydroxy-cyclohexyl)-amide

반응식

CO[C:3](=[O:8])[CH2:4][C:5](=O)[CH3:6].Br[CH2:10][C:11]([C:13]1[CH:18]=[C:17]([Cl:19])[CH:16]=[CH:15][C:14]=1[F:20])=O.[CH3:21][C:22]1([CH3:28])[CH2:24][C@@H:23]1[C:25]([NH2:27])=O.[H-].[H-].[H-].[H-].[Li+].[Al+3].[NH2:35][C@@H:36]1[CH2:41][CH2:40][CH2:39][CH2:38][C@H:37]1[OH:42]>>[OH:42][C@@H:37]1[CH2:38][CH2:39][CH2:40][CH2:41][C@H:36]1[NH:35][C:3]([C:4]1[CH:10]=[C:11]([C:13]2[CH:18]=[C:17]([Cl:19])[CH:16]=[CH:15][C:14]=2[F:20])[N:27]([CH2:25][C@H:23]2[CH2:24][C:22]2([CH3:28])[CH3:21])[C:5]=1[CH3:6])=[O:8]