Sodium Hydroxide → 1,1,-Difluoro-4-methyl-4-(2-methoxy-5-fluorophenyl)pentan-2-one

HRID 2106055노트

반응식

HRID 2106055 반응식
C(OP([C:9]([F:26])([F:25])[C:10](=[O:24])[CH2:11][C:12]([C:15]1[CH:20]=[C:19]([F:21])[CH:18]=[CH:17][C:16]=1[O:22][CH3:23])([CH3:14])[CH3:13])(=O)OCC)C.[OH-].[Na+]>CO.O>[F:26][CH:9]([F:25])[C:10](=[O:24])[CH2:11][C:12]([CH3:13])([C:15]1[CH:20]=[C:19]([F:21])[CH:18]=[CH:17][C:16]=1[O:22][CH3:23])[CH3:14]

참가 물질

5

반응물 2

HCID 14798Sodium HydroxideHCID 57809801[1,1-Difluoro-4-(5-fluoro-2-methoxyphenyl)-4-methyl-2-oxopentyl]phosphonic acid diethyl ester

생성물 1

HCID 578099691,1,-Difluoro-4-methyl-4-(2-methoxy-5-fluorophenyl)pentan-2-one수율 95.9%

시약·촉매·용매 2

HCID 887Methanol용매HCID 962Water용매2회

실험 절차

To a solution of [1,1-difluoro-4-(5-fluoro-2-methoxyphenyl)-4-methyl-2-oxopentyl]phosphonic acid diethyl ester (1.0 g) in methanol (12.0 mL) was added a solution of sodium hydroxide (0.04 g) in water (1 mL). The mixture was stirred at room temperature for 30 minutes. The mixture was diluted with hexanes (50 mL) and water (50 mL) and the organic phase was separated, dried, filtered, and evaporated in vacuo to give 1,1,-difluoro-4-methyl-4-(2-methoxy-5-fluorophenyl)pentan-2-one (0.63 g) as an oil which was used without additional purification.

후처리

  1. customthe organic phase was separated
  2. customdried
  3. filtrationfiltered
  4. customevaporated in vacuo

출처 및 근거

ORD 기록
ord-0044ed8a235c45e4b1ac87f2acfb4a03
출처 데이터셋
uspto-grants-2009_08
특허 번호
US07579469B2

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