Triethylamine → 3-fluoro-N-(1-methyl-1-phenylethyl)benzamide

HRID 21070

반응식

HRID 21070 반응식
[F:1][C:2]1[CH:3]=[C:4]([CH:8]=[CH:9][CH:10]=1)[C:5](Cl)=[O:6].[C:11]([NH2:20])([C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1)([CH3:13])[CH3:12].C(N(CC)CC)C>ClCCl.CN(C1C=CN=CC=1)C>[F:1][C:2]1[CH:3]=[C:4]([CH:8]=[CH:9][CH:10]=1)[C:5]([NH:20][C:11]([CH3:13])([C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1)[CH3:12])=[O:6]

참가 물질

6

반응물 3

HCID 8471TriethylamineHCID 68509CumylamineHCID 743763-Fluorobenzoyl chloride

생성물 1

HCID 474447463-fluoro-N-(1-methyl-1-phenylethyl)benzamide수율 95.3%

시약·촉매·용매 2

HCID 142844-(Dimethylamino)pyridine촉매HCID 6344Dichloromethane용매

실험 절차

In a similar manner to Step 1 of Example 16, 3-fluorobenzoyl chloride (2.00 g, 12.6 mmol) was dissolved in dichloromethane (40 mL), and the solution was treated with cumylamine (1.99 mL, 13.9 mmol), triethylamine (2.63 mL, 18.9 mmol) and DMAP (154 mg, 1.26 mmol). The mixture was purified by slurry using diisopropylether to obtain 3-fluoro-N-(1-methyl-1-phenylethyl)benzamide (3.09 g, yield 95%).

후처리

  1. customThe mixture was purified by slurry

출처 및 근거

ORD 기록
ord-604da105a25148b5894cebf65055674a
출처 데이터셋
uspto-grants-2010_06
특허 번호
US07745641B2

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