Triethylamine → 2-(p-Fluoroanilino)thiazole-4-carbaldehyde

HRID 2107275노트

반응식

HRID 2107275 반응식
[F:1][C:2]1[CH:15]=[CH:14][C:5]([NH:6][C:7]2[S:8][CH:9]=[C:10]([CH2:12][OH:13])[N:11]=2)=[CH:4][CH:3]=1.C(N(CC)CC)C>CS(C)=O>[F:1][C:2]1[CH:15]=[CH:14][C:5]([NH:6][C:7]2[S:8][CH:9]=[C:10]([CH:12]=[O:13])[N:11]=2)=[CH:4][CH:3]=1

참가 물질

4

반응물 2

HCID 8471TriethylamineHCID 150535552-p-Fluoroanilinothiazol-4-ylmethanol

생성물 1

HCID 150535722-(p-Fluoroanilino)thiazole-4-carbaldehyde

시약·촉매·용매 1

HCID 679Dimethyl Sulfoxide용매

실험 절차

The reaction described in Preparation 44 was repeated, but using 3.03 g of 2-p-fluoroanilinothiazol-4-ylmethanol, 8.5 g of pyridine sulfur trioxide complex, 7.5 ml of triethylamine and 140 ml of dimethyl sulfoxide. giving the title compound as pale brown prisms.

후처리

  1. customThe reaction described in Preparation 44

출처 및 근거

ORD 기록
ord-866a9f38546e4b30bba6e3e0351639df
출처 데이터셋
uspto-grants-1990_06
특허 번호
US04933355

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