Triethylamine → 3-methoxy-N-(1-methyl-1-phenylethyl)benzamide

HRID 21074

반응식

HRID 21074 반응식
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:9]=[CH:10][CH:11]=1)[C:6](Cl)=[O:7].[C:12]([NH2:21])([C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1)([CH3:14])[CH3:13].C(N(CC)CC)C>ClCCl.CN(C1C=CN=CC=1)C>[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:9]=[CH:10][CH:11]=1)[C:6]([NH:21][C:12]([CH3:14])([C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1)[CH3:13])=[O:7]

참가 물질

6

반응물 3

HCID 8471TriethylamineHCID 68509CumylamineHCID 74374m-Anisoyl chloride

생성물 1

HCID 474447523-methoxy-N-(1-methyl-1-phenylethyl)benzamide수율 98.2%

시약·촉매·용매 2

HCID 142844-(Dimethylamino)pyridine촉매HCID 6344Dichloromethane용매

실험 절차

In a similar manner to Step 1 of Example 16, 3-methoxybenzoylchloride (8.00 g, 46.9 mmol) was dissolved in dichloromethane (160 mL), and the solution was treated with cumylamine (7.40 mL, 51.6 mmol), triethylamine (9.80 mL, 70.4 mmol) and DMAP (573 mg, 4.69 mmol), followed by purification by slurry using diisopropylether to obtain 3-methoxy-N-(1-methyl-1-phenylethyl)benzamide (12.4 g, yield 98%).

후처리

  1. customfollowed by purification by slurry

출처 및 근거

ORD 기록
ord-3ae2376e5a64468fa46f09c86691de66
출처 데이터셋
uspto-grants-2010_06
특허 번호
US07745641B2

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