2-(2-Hydroxyethyl)pyridine → 2-[2-(4-Bromobutoxy)ethyl]pyridine

HRID 2108027노트

반응식

HRID 2108027 반응식
[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[CH2:7][CH2:8][OH:9].[Br:10][CH2:11][CH2:12][CH2:13][CH2:14]Br>>[Br:10][CH2:11][CH2:12][CH2:13][CH2:14][O:9][CH2:8][CH2:7][C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][N:1]=1

참가 물질

3

반응물 2

HCID 76752-(2-Hydroxyethyl)pyridineHCID 80561,4-Dibromobutane

생성물 1

HCID 230450722-[2-(4-Bromobutoxy)ethyl]pyridine수율 61.1%

실험 절차

From 2-pyridineethanol (5.0 g) and 1,4-dibromobutane (26.29 g), with a reaction time of 4 h. FCC eluting with ether-hexane (1:1) gave the title compound as a pale yellow oil (6.4 g), t.l.c. (ether-hexane 1:1) Rf 0.37.

후처리

  1. customwith a reaction time of 4 h
  2. washFCC eluting with ether-hexane (1:1)

출처 및 근거

ORD 기록
ord-700a49b178ca480f95329b8047d3a7fe
출처 데이터셋
uspto-grants-1990_06
특허 번호
US04937251

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