[NH:1]1[C:5]2=[N:6][CH:7]=[CH:8][CH:9]=[C:4]2[C:3]([C:10]2[S:14][C:13]([C:15]([O:17]CC)=[O:16])=[CH:12][CH:11]=2)=[CH:2]1.[OH-].[Na+].C(O)(=O)CC(CC(O)=O)(C(O)=O)O>O1CCOCC1.C(OCC)(=O)C>[NH:1]1[C:5]2=[N:6][CH:7]=[CH:8][CH:9]=[C:4]2[C:3]([C:10]2[S:14][C:13]([C:15]([OH:17])=[O:16])=[CH:12][CH:11]=2)=[CH:2]1Ethyl 5-(1H-pyrrolo[2,3-b]pyridin-3-yl)thiophene-2-carboxylate (0.89 g, 3.3 mmol) was partly dissolved in 1,4 dioxane and 10 mL 1N NaOH added. The reaction mixture was heated to 80° C. where it became homogenous. After 2 hours the reaction mixture was cooled to room temperature, diluted with ethyl acetate, and a 10% citric acid solution. A precipitate formed which was filtered off, washed with water and dried to 0.71 g, 2.9 mmol, 88% yield.
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