참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Iodine | HCID 807 | — |
| 반응물 | 2-Pyridinamine, N-methyl- | HCID 20727 | — |
| 반응물 | Sodium Bicarbonate | HCID 516892 | — |
| 용매 | Acetic Acid | HCID 176 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | (5-Iodo-pyridin-2-yl)-methyl-amine | HCID 11253290 | 24.9% |
반응 단계
To a solution of 2-methylaminopyridine (Aldrich; 1.00 g, 9.25 mmol) in 10 mL of 1:1 HOAc and water was added 2.35 g (9.25 mmol) of I2. The resulting brown solution was heated to 80° C. for 3 h. After cooling to room temperature, the mixture was neutralized with saturated NaHCO3 and extracted with Et2O. The extract was washed with water and brine, dried with MgSO4, filtered, and concentrated to provide 540 mg of (5-iodo-pyridin-2-yl)-methyl-amine.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US07514458B2 |
|---|
| 출처 데이터셋 | uspto-grants-2009_04 |
|---|
| ORD ID | ord-3ad8aeb0ab5848fbbff8dd26fcbe6a44 |
|---|
| 출처 메모 | uspto-grants-2009_04 |
|---|
