反应详情

温度

80 °C

To a solution of 2-methylaminopyridine (Aldrich; 1.00 g, 9.25 mmol) in 10 mL of 1:1 HOAc and water was added 2.35 g (9.25 mmol) of I2. The resulting brown solution was heated to 80° C. for 3 h. After cooling to room temperature, the mixture was neutralized with saturated NaHCO3 and extracted with Et2O. The extract was washed with water and brine, dried with MgSO4, filtered, and concentrated to provide 540 mg of (5-iodo-pyridin-2-yl)-methyl-amine.

1. temperatureAfter cooling to room temperature
2. extractionextracted with Et2O
3. washThe extract was washed with water and brine
4. dry with materialdried with MgSO4
5. filtrationfiltered
6. concentrationconcentrated