4-Bromophenol → HCID 23062453, 화합물

HRID 2109374

반응식

HRID 2109374 반응식
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([OH:8])=[CH:4][CH:3]=1.[CH3:9][C:10]1[C:17]([CH3:18])=[CH:16][C:15]([CH3:19])=[C:14]([CH3:20])[C:11]=1[CH2:12]Cl.C(=O)([O-])[O-].[K+].[K+]>CC(C)=O>[CH3:20][C:14]1[C:15]([CH3:19])=[CH:16][C:17]([CH3:18])=[C:10]([CH3:9])[C:11]=1[CH2:12][O:8][C:5]1[CH:6]=[CH:7][C:2]([Br:1])=[CH:3][CH:4]=1

참가 물질

5

반응물 3

HCID 78084-BromophenolHCID 11430Potassium CarbonateHCID 819393-(Chloromethyl)-1,2,4,5-tetramethylbenzene

생성물 1

HCID 23062453HCID 23062453, 화합물수율 79%

시약·촉매·용매 1

HCID 180Acetone용매

실험 절차

In acetone (50 ml), a mixture of 4-bromophenol (7.8 g), 2,3,5,6-tetramethylbenzyl chloride (6.3 g) and potassium carbonate (6.5 g) was heated at reflux for 16 hours. The reaction solution was filtered, and the filtrate was concentrated under reduced pressure. The residue was dissolved in ethyl acetate, and successively washed with 3% aqueous sodium hydroxide solution, water and saturated brine. The solvent was evaporated under reduced pressure, thereby giving 8.7 g of the desired compound.

후처리

  1. temperaturewas heated
  2. temperatureat reflux for 16 hours
  3. filtrationThe reaction solution was filtered
  4. concentrationthe filtrate was concentrated under reduced pressure
  5. dissolutionThe residue was dissolved in ethyl acetate
  6. washsuccessively washed with 3% aqueous sodium hydroxide solution, water and saturated brine
  7. customThe solvent was evaporated under reduced pressure

출처 및 근거

ORD 기록
ord-52c09326b92d4d6db679987c70e3e86c
출처 데이터셋
uspto-grants-2009_04
특허 번호
US07514452B2

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