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llms.txt · MCP 가이드개인정보처리방침 · 이용약관 · 지원v1.8.0
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Acetic Acid → (S)-7-cyclopropyl-N-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-3-phenyl-5,6,7,8-tetrahydroimidazo[1,5-a]pyrazine-1-carboxamide

HRID 2110197
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HRID 2110197 반응식
[CH3:1][C:2]([CH3:27])([CH3:26])[C@H:3]([NH:8][C:9]([C:11]1[N:12]=[C:13]([C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)[N:14]2[CH2:19][CH2:18][NH:17][CH2:16][C:15]=12)=[O:10])[C:4]([NH:6][CH3:7])=[O:5].C(O[C:31]1(O[Si](C)(C)C)[CH2:33][CH2:32]1)C.C([BH3-])#N.[Na+].C(O)(=O)C>CO>[CH:31]1([N:17]2[CH2:18][CH2:19][N:14]3[C:13]([C:20]4[CH:21]=[CH:22][CH:23]=[CH:24][CH:25]=4)=[N:12][C:11]([C:9]([NH:8][C@@H:3]([C:2]([CH3:27])([CH3:26])[CH3:1])[C:4]([NH:6][CH3:7])=[O:5])=[O:10])=[C:15]3[CH2:16]2)[CH2:33][CH2:32]1
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참가 물질

6

반응물 4

HCID 176Acetic AcidHCID 2734686(1-Ethoxycyclopropoxy)trimethylsilaneHCID 5003444Sodium cyanoborohydrideHCID 25132789(S)-N-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-3-phenyl-5,6,7,8-tetrahydroimidazo[1,5-a]pyrazine-1-carboxamide

생성물 1

HCID 57635385(S)-7-cyclopropyl-N-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-3-phenyl-5,6,7,8-tetrahydroimidazo[1,5-a]pyrazine-1-carboxamide

시약·촉매·용매 1

HCID 887Methanol용매

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온도
60 °C

실험 절차

Compound 2 (60 mg, 0.16 mmol) was dissolved in methanol and (1-ethoxycyclopropoxy)trimethylsilane (170 mg, 0.94 mmol) was added followed by sodium cyanoborohydride (46 mg, 0.73 mmol) and acetic acid (98 mg, 1.62 mmol). The reaction mixture was heated at 60° C. overnight, cooled down to room temperature, filtered and concentrated.

후처리

  1. temperaturecooled down to room temperature
  2. filtrationfiltered
  3. concentrationconcentrated

출처 및 근거

ORD 기록
ord-9f410be3af2948eb84cc9ed2ece0fb2e
출처 데이터셋
uspto-grants-2009_04
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US07517874B2

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