Sodium Hydroxide → 5-Chloronaphthalen-1-amine

HRID 2110412노트

반응식

HRID 2110412 반응식
[NH:1]([C:5]1[C:14]2[C:9](=[C:10]([Cl:15])[CH:11]=[CH:12][CH:13]=2)[CH:8]=[CH:7][CH:6]=1)C(C)=O.[OH-].[Na+]>CCO>[NH2:1][C:5]1[C:14]2[C:9](=[C:10]([Cl:15])[CH:11]=[CH:12][CH:13]=2)[CH:8]=[CH:7][CH:6]=1

참가 물질

4

반응물 2

HCID 14798Sodium HydroxideHCID 218748441-Acetamino-5-chloronaphthalene

생성물 1

HCID 44550535-Chloronaphthalen-1-amine수율 98%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

A solution of the above synthesized 1-acetamino-5-chloronaphthalene (52 mg, 0.24 mmol) in 3 mL EtOH was heated to reflux and treated with 0.5 mL 40% aqueous NaOH solution. The mixture was refluxed until no more starting material could be detected, cooled and concentrated under reduced pressure. The residue was taken up in CH2Cl2 (50 mL) and was washed with H2O (25 mL). The organic layer was dried over MgSO4 and concentrated in vacuo to leave 41 mg (98%) of compound 213A as a white solid.

후처리

  1. temperaturewas heated
  2. temperatureto reflux
  3. temperatureThe mixture was refluxed until
  4. temperaturecooled
  5. concentrationconcentrated under reduced pressure
  6. washwas washed with H2O (25 mL)
  7. dry with materialThe organic layer was dried over MgSO4
  8. concentrationconcentrated in vacuo

출처 및 근거

ORD 기록
ord-5a74b0f3047b4c278fa67d074882f72b
출처 데이터셋
uspto-grants-2009_04
특허 번호
US07517904B2

반응 노트

불러오는 중…