Iodine → 4-Chloro-7-[1-(tert-butoxycarbonyl)-3-iodoindol-2-yl]isoindolinone

HRID 21108

반응식

HRID 21108 반응식
[Cl:1][C:2]1[CH:10]=[CH:9][C:8]([C:11]2[N:12]([C:20]([O:22][C:23]([CH3:26])([CH3:25])[CH3:24])=[O:21])[C:13]3[C:18]([CH:19]=2)=[CH:17][CH:16]=[CH:15][CH:14]=3)=[C:7]2[C:3]=1[CH2:4][NH:5][C:6]2=[O:27].[I:28]I>C(O)C.S([O-])([O-])(=O)=O.[Ag+2]>[Cl:1][C:2]1[CH:10]=[CH:9][C:8]([C:11]2[N:12]([C:20]([O:22][C:23]([CH3:24])([CH3:26])[CH3:25])=[O:21])[C:13]3[C:18]([C:19]=2[I:28])=[CH:17][CH:16]=[CH:15][CH:14]=3)=[C:7]2[C:3]=1[CH2:4][NH:5][C:6]2=[O:27]

참가 물질

5

반응물 2

HCID 807IodineHCID 684875944-Chloro-7-(1-(tert-butoxycarbonyl)indol-2-yl)isoindolinone

생성물 1

HCID 684922044-Chloro-7-[1-(tert-butoxycarbonyl)-3-iodoindol-2-yl]isoindolinone수율 36%

시약·촉매·용매 2

HCID 178418844HCID 178418844, 화합물촉매HCID 702Ethanol용매

실험 절차

In a similar manner to Step 1 of Example 161, 4-chloro-7-(1-(tert-butoxycarbonyl)-indol-2-yl)isoindolinone (374 mg, 0.980 mmol) was dissolved in ethanol (26 mL), and the solution was treated with iodine (299 mg, 1.18 mmol) and silver sulfate (306 mg, 0.980 mmol), followed by purification by slurry using hexane and diisopropylether to obtain 4-chloro-7-[1-(tert-butoxycarbonyl)-3-iodoindol-2-yl]isoindolinone (179 mg, yield 36%).

후처리

  1. customfollowed by purification by slurry

출처 및 근거

ORD 기록
ord-e091ca1a6fd64562984b79a3781fd88c
출처 데이터셋
uspto-grants-2010_06
특허 번호
US07745641B2

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