4-(Chloromethyl)benzaldehyde → 4-Chloromethylbenzaldehyde oxime
반응식
[Cl:1][CH2:2][C:3]1[CH:10]=[CH:9][C:6]([CH:7]=O)=[CH:5][CH:4]=1.Cl.[NH2:12][OH:13]>C(O)C>[Cl:1][CH2:2][C:3]1[CH:10]=[CH:9][C:6]([CH:7]=[N:12][OH:13])=[CH:5][CH:4]=1참가 물질
4
반응 조건
- 온도
- 50 °C
실험 절차
4-Chloromethylbenzaldehyde (11.93 g, 77.17 mmol) was dissolved in ethanol (200 ml), hydroxylamine hydrochloride (10.73 g, 154.41 mmol) was added, and the mixture was stirred at 50° C. for 3 hours. Ethanol was evaporated under reduced pressure, water was added, and the mixture was extracted with ethyl acetate. The extract was washed with saturated brine and dried over anhydrous sodium sulfate. The solvent was evaporated under reduced pressure to give the title compound (12.69 g, 97%).
후처리
- customEthanol was evaporated under reduced pressure, water
- additionwas added
- extractionthe mixture was extracted with ethyl acetate
- washThe extract was washed with saturated brine
- dry with materialdried over anhydrous sodium sulfate
- customThe solvent was evaporated under reduced pressure
출처 및 근거
- ORD 기록
- ord-bac323ceca1f4a00a7b0d4c70678c65c
- 출처 데이터셋
- uspto-grants-2009_04
- 특허 번호
- US07517996B2
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