3-Fluoro-4-hydroxybenzeneacetic acid → N-Benzyl-2-(3-fluoro-4-hydroxyphenyl)-N-hexylacetamide

HRID 2111988

반응식

HRID 2111988 반응식
[F:1][C:2]1[CH:3]=[C:4]([CH2:9][C:10]([OH:12])=O)[CH:5]=[CH:6][C:7]=1[OH:8].[CH2:13]([NH:19][CH2:20][C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1)[CH2:14][CH2:15][CH2:16][CH2:17][CH3:18].CN(C(ON1N=NC2C=CC=CC1=2)=[N+](C)C)C.[B-](F)(F)(F)F.CCN(C(C)C)C(C)C>CN(C=O)C>[CH2:20]([N:19]([CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH3:18])[C:10](=[O:12])[CH2:9][C:4]1[CH:5]=[CH:6][C:7]([OH:8])=[C:2]([F:1])[CH:3]=1)[C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1

참가 물질

6

반응물 4

HCID 680143-Fluoro-4-hydroxybenzeneacetic acidHCID 81531DiisopropylethylamineHCID 485395Benzenemethanamine, N-hexyl-HCID 2733207O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate

생성물 1

HCID 68871257N-Benzyl-2-(3-fluoro-4-hydroxyphenyl)-N-hexylacetamide수율 77.2%

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

3-Fluoro-4-hydroxyphenylacetic acid (170 mg, 0.999 mmol) dissolved in DMF (3 ml) was cooled in an ice-bath N-Hexylbenzylamine (201 mg, 1.049 mmol) was added and then TBTU (337 mg, 1.049 mmol) followed by DIPEA (407 mg, 3.147 mmol). The mixture was stirred at room temperature overnight and evaporated. Sodium hydrogencarbonate aqueous solution (sat.) was added into the residue. The mixture was then extracted with ethyl acetate (×2). The extracts were combined and washed with water and brine and dried (magnesium sulphate) and evaporated. Chromatography of the residue on a column (ISOLUTE® SI, 5 g/15 ml) using DCM and then MeOH/DCM (1:99) as eluant gave 265 mg the desired product, yield 77%.

후처리

  1. additionwas added
  2. customevaporated
  3. additionSodium hydrogencarbonate aqueous solution (sat.) was added into the residue
  4. extractionThe mixture was then extracted with ethyl acetate (×2)
  5. washwashed with water and brine
  6. dry with materialdried (magnesium sulphate)
  7. customevaporated

출처 및 근거

ORD 기록
ord-cc98671f87b84a8e8507afecc439120f
출처 데이터셋
uspto-grants-2009_04
특허 번호
US07521461B2

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