Potassium Carbonate → methyl 2-[(4-{2-[4-(1H-imidazol-1-yl)phenoxy]ethyl}phenoxy)methyl]benzoate

HRID 2111999

반응식

HRID 2111999 반응식
CS([O:5][CH2:6][CH2:7][C:8]1[CH:25]=[CH:24][C:11]([O:12][CH2:13][C:14]2[CH:23]=[CH:22][CH:21]=[CH:20][C:15]=2[C:16]([O:18][CH3:19])=[O:17])=[CH:10][CH:9]=1)(=O)=O.[N:26]1([C:31]2[CH:36]=[CH:35][C:34](O)=[CH:33][CH:32]=2)[CH:30]=[CH:29][N:28]=[CH:27]1.C(=O)([O-])[O-].[K+].[K+]>C(#N)C>[N:26]1([C:31]2[CH:36]=[CH:35][C:34]([O:5][CH2:6][CH2:7][C:8]3[CH:25]=[CH:24][C:11]([O:12][CH2:13][C:14]4[CH:23]=[CH:22][CH:21]=[CH:20][C:15]=4[C:16]([O:18][CH3:19])=[O:17])=[CH:10][CH:9]=3)=[CH:33][CH:32]=2)[CH:30]=[CH:29][N:28]=[CH:27]1

참가 물질

5

반응물 3

HCID 11430Potassium CarbonateHCID 823151-(p-Hydroxyphenyl)imidazoleHCID 86601923Methyl 2-[(4-{2-[(methylsulfonyl)oxy]ethyl}phenoxy)methyl]benzoate

생성물 1

HCID 68869830methyl 2-[(4-{2-[4-(1H-imidazol-1-yl)phenoxy]ethyl}phenoxy)methyl]benzoate수율 113.7%

시약·촉매·용매 1

HCID 6342Acetonitrile용매

반응 조건

온도
75 °C

실험 절차

Methyl 2-[(4-{2-[(methylsulfonyl)oxy]ethyl}phenoxy)methyl]benzoate (0.2 g, 0.55 mmol) and 4-(1H-imidazol-1-yl)phenol (0.11 g, 0.66 mmol) was dissolved in acetonitrile (10 ml) and potassium carbonate (0.09 g, 0.66 mmol) was added. The mixture was stirred over night at 75° C. Remove the acetonitrile by evaporation, dilute with EtOAc (10 ml) and wash the organic phase with Brine three times, dry (MgSO4) and evaporate. This gave 0.268 g of methyl 2-[(4-{2-[4-(1H-imidazol-1-yl)phenoxy]ethyl}phenoxy)methyl]benzoate (yield 90%).

후처리

  1. customRemove the acetonitrile
  2. customby evaporation
  3. additiondilute with EtOAc (10 ml)
  4. washwash the organic phase with Brine three times
  5. dry with materialdry (MgSO4)
  6. customevaporate

출처 및 근거

ORD 기록
ord-eabb4deeb9264e45adee50c353f77ca3
출처 데이터셋
uspto-grants-2009_04
특허 번호
US07521461B2

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