Sodium Hydroxide → 2-Amino-5-fluorobenzenesulfonamide

HRID 2112561노트

반응식

HRID 2112561 반응식
[F:1][C:2]1[CH:14]=[CH:13][C:5]2[NH:6]C(=O)[NH:8][S:9](=[O:11])(=[O:10])[C:4]=2[CH:3]=1.[OH-].[Na+]>S(=O)(=O)(O)O>[NH2:6][C:5]1[CH:13]=[CH:14][C:2]([F:1])=[CH:3][C:4]=1[S:9]([NH2:8])(=[O:11])=[O:10]

참가 물질

4

반응물 2

HCID 14798Sodium HydroxideHCID 110960067-Fluoro-2H-benzo[e][1,2,4]thiadiazin-3(4H)-one 1,1-dioxide

생성물 1

HCID 224818252-Amino-5-fluorobenzenesulfonamide

시약·촉매·용매 1

HCID 1118Sulfuric Acid용매

반응 조건

온도
130 °C

실험 절차

After suspending 7-fluoro-2H,4H-benzo[e]1,2,4-thiadiazine-1,1,3-trione (3.00 g, 13.9 mmol) in 50% sulfuric acid (90 mL), the mixture was stirred at 130° C. for 1 hour. The reaction mixture was cooled in an ice bath while adding 40% aqueous sodium hydroxide for neutralization. The aqueous solution was concentrated under reduced pressure to 200 mL, and the precipitate was filtered out. It was then suspended in ethyl acetate (100 mL), and the insoluble portion was filtered out. The filtrate was concentrated under reduced pressure and dried to obtain 2-amino-5-fluorobenzenesulfonamide.

후처리

  1. temperatureThe reaction mixture was cooled in an ice bath
  2. concentrationThe aqueous solution was concentrated under reduced pressure to 200 mL
  3. filtrationthe precipitate was filtered out
  4. filtrationthe insoluble portion was filtered out
  5. concentrationThe filtrate was concentrated under reduced pressure
  6. customdried

출처 및 근거

ORD 기록
ord-56b4425951284b84b419c32c38a91b0f
출처 데이터셋
uspto-grants-2009_04
특허 번호
US07524841B2

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