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Sodium Hydroxide → 4-hydroxy-3-(4-methoxyphenyl)benzyl Alcohol

HRID 2113107
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HRID 2113107 반응식
[OH:1][C:2]1[CH:12]=[CH:11][C:5]([C:6](OCC)=[O:7])=[CH:4][C:3]=1[C:13]1[CH:18]=[CH:17][C:16]([O:19][CH3:20])=[CH:15][CH:14]=1.OC1C=CC(C(O)=O)=CC=1C1C=CC(OC)=CC=1.[H-].[H-].[H-].[H-].[Li+].[Al+3].[OH-].[Na+]>C1COCC1>[OH:1][C:2]1[CH:12]=[CH:11][C:5]([CH2:6][OH:7])=[CH:4][C:3]=1[C:13]1[CH:18]=[CH:17][C:16]([O:19][CH3:20])=[CH:15][CH:14]=1
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

6

반응물 4

HCID 14798Sodium HydroxideHCID 21226445Aluminium lithium hydrideHCID 223911504-Hydroxy-3-(4-methoxyphenyl)benzoic acidHCID 22391340HCID 22391340, 화합물

생성물 1

HCID 688406354-hydroxy-3-(4-methoxyphenyl)benzyl Alcohol

시약·촉매·용매 1

HCID 8028Tetrahydrofuran
용매

실험 절차

A solution of Ethyl 4-hydroxy-3-(4-methoxyphenyl)benzoate and 4-hydroxy-3-(4-methoxyphenyl)benzoic acid (5.3 g, 19.47 mmol) in anhydrous THF (100 mL) was cooled to 0° C. and treated with LiAlH4 (2.95 g, 77.8 mmol); the mixture was then heated at 65 C for one hour then cooled and aqueous NaOH (5%, 19.4 mL) was added drop wise. The resulting precipitate was filtered off and the filtrate concentrated under reduced pressure to afford 5.54 g of crude product.

후처리

  1. temperaturethe mixture was then heated at 65 C for one hour
  2. temperaturethen cooled
  3. filtrationThe resulting precipitate was filtered off
  4. concentrationthe filtrate concentrated under reduced pressure

출처 및 근거

ORD 기록
ord-f1bbf514e6514d67ad788f40319e3285
출처 데이터셋
uspto-grants-2009_04
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US07524873B2

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