Phenol → 5-[3-(4-tert-Butyl-2-chloro-phenoxy)-propoxy]-2-ethyl-2,3-dihydro-benzofuran-2-carboxylic acid
반응식
[Cl:1][C:2]1[CH:7]=[C:6]([C:8]([CH3:11])([CH3:10])[CH3:9])[CH:5]=[CH:4][C:3]=1[OH:12].[I-].C[O:15][C:16]([C:18]1([CH2:28][CH3:29])[CH2:22][C:21]2[CH:23]=[C:24]([OH:27])[CH:25]=[CH:26][C:20]=2[O:19]1)=[O:17].[C:30]1(O)[CH:35]=CC=C[CH:31]=1>>[C:8]([C:6]1[CH:5]=[CH:4][C:3]([O:12][CH2:31][CH2:30][CH2:35][O:27][C:24]2[CH:25]=[CH:26][C:20]3[O:19][C:18]([CH2:28][CH3:29])([C:16]([OH:15])=[O:17])[CH2:22][C:21]=3[CH:23]=2)=[C:2]([Cl:1])[CH:7]=1)([CH3:9])([CH3:11])[CH3:10]참가 물질
5
실험 절차
The title compound was prepared following the general procedures described Example 1, Step 3 and Step 4, employing 2-chloro-4-tert-butylphenol instead of 2-chloro-4-(trifluoroethoxy)phenol for the preparation of the iodide and the intermediate prepared in Example 4, Step 1 as the phenol for coupling with the iodide.