Cesium carbonate → Methyl 6-methoxybenzofuran-2-carboxylate
반응식
Br[CH2:2][C:3]([O:5][CH3:6])=[O:4].[OH:7][C:8]1[CH:15]=[C:14]([O:16][CH3:17])[CH:13]=[CH:12][C:9]=1[CH:10]=O.C([O-])([O-])=O.[Cs+].[Cs+]>CN(C=O)C.C(OCC)(=O)C>[CH3:6][O:5][C:3]([C:2]1[O:7][C:8]2[CH:15]=[C:14]([O:16][CH3:17])[CH:13]=[CH:12][C:9]=2[CH:10]=1)=[O:4]참가 물질
6
반응 조건
- 온도
- 50 °C
실험 절차
A mixture of methyl bromoacetate (1.53 g, 10 mmol), 2-hydroxy-4-methoxybenzaldehyde (1.52 g, 10 mmol) and Cs2CO3 (6.5 g, 20 mmol) in DMF (100 mL) was stirred vigorously at 50° C. for 3 hrs and then at 150° C. for 5 min. The reaction was cooled, diluted with ethyl acetate and washed with water. The organic phase was dried and concentrated to give essentially pure 6-methoxy-benzofuran-2-carboxylic acid methyl ester as a solid.
후처리
- waitat 150° C. for 5 min
- temperatureThe reaction was cooled
- washwashed with water
- customThe organic phase was dried
- concentrationconcentrated
출처 및 근거
- ORD 기록
- ord-bd952c834afe4e92806ea9bf045a73d9
- 출처 데이터셋
- uspto-grants-2009_04
- 특허 번호
- US07524882B2
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