Chlorosuccinimide → 3-Chloro-1H-indole-5-carboxylic acid methyl ester

HRID 2113468

반응식

HRID 2113468 반응식
[CH3:1][O:2][C:3]([C:5]1[CH:6]=[C:7]2[C:11](=[CH:12][CH:13]=1)[NH:10][CH:9]=[CH:8]2)=[O:4].[Cl:14]N1C(=O)CCC1=O>CO>[CH3:1][O:2][C:3]([C:5]1[CH:6]=[C:7]2[C:11](=[CH:12][CH:13]=1)[NH:10][CH:9]=[C:8]2[Cl:14])=[O:4]

참가 물질

4

반응물 2

HCID 31398ChlorosuccinimideHCID 2737635methyl 1H-indole-5-carboxylate

생성물 1

HCID 219987283-Chloro-1H-indole-5-carboxylic acid methyl ester수율 62.6%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

A mixture of 1.4 g (8 mmol) 1H-indole-5-carboxylic acid methyl ester and 1.28 g (9.6 mmol) N-chlorosuccinimid in 40 mL methanol was stirred at room temperature for 16 h. The mixture was evaporated to dryness and taken up in DCM washed with 1N NaHCO3 aq, dried with MgSO4, filtered and evaporated to dryness to yield 1.05 g (62%) of the title compound. MS(m/e): 210.1 (MH+).

후처리

  1. customThe mixture was evaporated to dryness
  2. washwashed with 1N NaHCO3 aq
  3. dry with materialdried with MgSO4
  4. filtrationfiltered
  5. customevaporated to dryness

출처 및 근거

ORD 기록
ord-3b5c17169e574e9a83ea3a80bfdc003e
출처 데이터셋
uspto-grants-2008_10
특허 번호
US07432255B2

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