Phosphorus oxychloride → 2-Chloro-4-(4-fluorophenyl)pyridine

HRID 2113545노트

반응식

HRID 2113545 반응식
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:13]=[CH:12][N+:11]([O-])=[CH:10][CH:9]=2)=[CH:4][CH:3]=1.P(Cl)(Cl)([Cl:17])=O>>[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:13]=[CH:12][N:11]=[C:10]([Cl:17])[CH:9]=2)=[CH:4][CH:3]=1

참가 물질

3

반응물 2

HCID 24813Phosphorus oxychlorideHCID 187002504-(4-Fluoro-phenyl)-pyridine 1-oxide

생성물 1

HCID 231207302-Chloro-4-(4-fluorophenyl)pyridine

실험 절차

A mixture of 0.9 g (4.8 mmol) of 4-(4-fluorophenyl)pyridine-1-oxide and 10 mL of phosphoryl chloride is heated at reflux overnight.

후처리

  1. temperatureis heated
  2. temperatureat reflux overnight

출처 및 근거

ORD 기록
ord-921ad7bfd8214392960609e59c5cf2cb
출처 데이터셋
uspto-grants-2008_10
특허 번호
US07432269B2

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