Sodium Hydroxide → HCID 6483399, 화합물

HRID 2113815노트

반응식

HRID 2113815 반응식
[OH-].[Na+].C[O:4][C:5](=[O:17])[C:6]1[CH:11]=[C:10]([OH:12])[CH:9]=[C:8]([O:13][CH:14]([CH3:16])[CH3:15])[CH:7]=1>CO>[OH:12][C:10]1[CH:9]=[C:8]([O:13][CH:14]([CH3:16])[CH3:15])[CH:7]=[C:6]([CH:11]=1)[C:5]([OH:17])=[O:4]

참가 물질

4

반응물 2

HCID 14798Sodium HydroxideHCID 23072925Methyl 3-hydroxy-5-isopropoxybenzoate

생성물 1

HCID 6483399HCID 6483399, 화합물수율 87%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

After adding 10 ml of 4N aqueous sodium hydroxide solution to a solution of the 3.0 g (14.3 mmol) of 5-hydroxy-3-isopropoxybenzoic acid methyl ester obtained in Production Example 59 in methanol (50 ml), the mixture was stirred at room temperature for 12 hours. The reaction mixture was concentrated under reduced pressure, and then saturated aqueous ammonium chloride was added, extraction was performed with chloroform, and the organic layer was dried and then concentrated under reduced pressure. The obtained residue was purified by silica gel chromatography (chloroform:methanol=50:1) to obtain 2.44 g of 5-hydroxy-3-isopropoxybenzoic acid (yield: 87%) as a white solid.

후처리

  1. concentrationThe reaction mixture was concentrated under reduced pressure
  2. additionsaturated aqueous ammonium chloride was added
  3. extractionextraction
  4. customthe organic layer was dried
  5. concentrationconcentrated under reduced pressure
  6. customThe obtained residue was purified by silica gel chromatography (chloroform:methanol=50:1)

출처 및 근거

ORD 기록
ord-9483fb199cad47a2bbb1dbfa8de292cf
출처 데이터셋
uspto-grants-2008_10
특허 번호
US07432287B2

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