1-Methylpiperazine → HCID 44578630, 화합물

HRID 2114097노트

반응식

HRID 2114097 반응식
Cl[C:2]1[CH:3]=[C:4]([CH:28]=[CH:29][N:30]=1)[C:5]([NH:7][C:8]1[CH:9]=[C:10]([C:15]2[CH:20]=[CH:19][C:18]([C:21]([NH:23][CH2:24][CH:25]3[CH2:27][CH2:26]3)=[O:22])=[CH:17][CH:16]=2)[C:11]([CH3:14])=[CH:12][CH:13]=1)=[O:6].[CH3:31][N:32]1[CH2:37][CH2:36][NH:35][CH2:34][CH2:33]1>>[CH:25]1([CH2:24][NH:23][C:21]([C:18]2[CH:19]=[CH:20][C:15]([C:10]3[C:11]([CH3:14])=[CH:12][CH:13]=[C:8]([NH:7][C:5](=[O:6])[C:4]4[CH:28]=[CH:29][N:30]=[C:2]([N:35]5[CH2:36][CH2:37][N:32]([CH3:31])[CH2:33][CH2:34]5)[CH:3]=4)[CH:9]=3)=[CH:16][CH:17]=2)=[O:22])[CH2:27][CH2:26]1

참가 물질

3

반응물 2

HCID 531671-MethylpiperazineHCID 44578670HCID 44578670, 화합물

생성물 1

HCID 44578630HCID 44578630, 화합물

실험 절차

N-(4′-{[(Cyclopropylmethyl)amino]carbonyl}-6-methyl-1,1′-biphenyl-3-yl)-2-(4-methylpiperazin-1-yl)isonicotinamide was prepared from 2-chloro-N-(4′-{[(cyclopropylmethyl)amino]carbonyl}-6-methyl-1,1′-biphenyl-3yl)isonicotinamide and N-methylpiperazine using method A. NMR; δH [2H6]—DMSO 10.31,(1H, s), 8.62,(1H, t), 8.24,(1H, d), 7.93,(2H, d), 7.71,(1H, dd), 7.64,(1H, d), 7.44,(2H, d), 7.30,(1H, d), 7.23,(1H, s), 7.06,(1H, d), 3.55,(4H, m), 3.16,(2H, t), 2.40,(4H, t), 2.21,(6H, m), 1.04,(1H, m), 0.43,(2H, m), 0.24,(2H, m). LCMS: retention time 2.74 min, MH+484.

출처 및 근거

ORD 기록
ord-cdf1da84fa3f4169a4d4c405d16a3671
출처 데이터셋
uspto-grants-2008_10
특허 번호
US07432289B2

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