Sodium Hydroxide → 3-(2,2'-Bisethylcarbamoyl-2-phenylethoxy)propionic acid

HRID 2114184노트

반응식

HRID 2114184 반응식
C[O:2][C:3](=[O:25])[CH2:4][CH2:5][O:6][CH2:7][C:8]([C:20](=[O:24])[NH:21][CH2:22][CH3:23])([C:15](=[O:19])[NH:16][CH2:17][CH3:18])[C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1.[OH-].[Na+]>C1COCC1.CO>[CH2:17]([NH:16][C:15]([C:8]([C:20](=[O:24])[NH:21][CH2:22][CH3:23])([C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1)[CH2:7][O:6][CH2:5][CH2:4][C:3]([OH:25])=[O:2])=[O:19])[CH3:18]

참가 물질

5

반응물 2

HCID 14798Sodium HydroxideHCID 587063943-(2,2'-Bisethylcarbamoyl-2-phenylethoxy)propionic acid methyl ester

생성물 1

HCID 587063833-(2,2'-Bisethylcarbamoyl-2-phenylethoxy)propionic acid수율 95.8%

시약·촉매·용매 2

HCID 887Methanol용매HCID 8028Tetrahydrofuran용매

실험 절차

3-(2,2′-Bisethylcarbamoyl-2-phenylethoxy)propionic acid methyl ester (125 mg) was dissolved in THF (0.5 mL) and MeOH (0.5 mL), and 1N sodium hydroxide (0.5 mL) was added thereto. The solution was stirred at room temperature for 1 hour and then concentrated. The residue was acidified with 1N hydrochloric acid and extracted with ethyl acetate. The extract was washed with water and concentrated to give 3-(2,2′-bisethylcarbamoyl-2-phenylethoxy)propionic acid (115 mg).

후처리

  1. concentrationconcentrated
  2. extractionextracted with ethyl acetate
  3. washThe extract was washed with water
  4. concentrationconcentrated

출처 및 근거

ORD 기록
ord-3ca82c3ad52940c8bf431d4ebb6d5cac
출처 데이터셋
uspto-grants-2008_10
특허 번호
US07432392B2

반응 노트

불러오는 중…