3-Fluorobenzenesulfonyl Chloride → HCID 69317589, 화합물

HRID 2114611노트

반응식

HRID 2114611 반응식
[CH:1]1([N:6]2[C:10]3[N:11]=[CH:12][N:13]=[C:14]([NH2:15])[C:9]=3[C:8]([C:16]3[NH:20][C:19]4[CH:21]=[C:22]([N+:25]([O-])=O)[CH:23]=[CH:24][C:18]=4[N:17]=3)=[CH:7]2)[CH2:5][CH2:4][CH2:3][CH2:2]1.[F:28][C:29]1[CH:30]=[C:31]([S:35](Cl)(=[O:37])=[O:36])[CH:32]=[CH:33][CH:34]=1>CS(C)=O>[NH2:15][C:14]1[C:9]2[C:8]([C:16]3[NH:20][C:19]4[CH:21]=[C:22]([NH:25][S:35]([C:31]5[CH:32]=[CH:33][CH:34]=[C:29]([F:28])[CH:30]=5)(=[O:37])=[O:36])[CH:23]=[CH:24][C:18]=4[N:17]=3)=[CH:7][N:6]([CH:1]3[CH2:5][CH2:4][CH2:3][CH2:2]3)[C:10]=2[N:11]=[CH:12][N:13]=1

참가 물질

4

반응물 2

HCID 27342583-Fluorobenzenesulfonyl ChlorideHCID 69320502HCID 69320502, 화합물

생성물 1

HCID 69317589HCID 69317589, 화합물

시약·촉매·용매 1

HCID 679Dimethyl Sulfoxide용매

실험 절차

The title compound was prepared by treatment of 5-(6-Amino-1H-benzoimidazol-2-yl)-7-cyclopentyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylamine (1E, 20 mg in 1.0 mL NMP) with 1.2 equiv. of 3-fluoro-benzenesulfonyl chloride (14.3 mg) at 80° C. for 2.5 h. LCMS was used to confirm product formation and the resulting reaction mixture was diluted with 1.0 mL DMSO and purified via preparative HPLC to furnish the desired product (M/Z 491.2, retention time 2.3 min. with analytical HPLC method 2).

후처리

  1. customthe resulting reaction mixture
  2. custompurified via preparative HPLC

출처 및 근거

ORD 기록
ord-39018f5132b94d84a3ceb109ed094aa9
출처 데이터셋
uspto-grants-2008_10
특허 번호
US07435739B2

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