Hydrazine hydrate (1:1) → 1-Ethyl-7-fluoro-1,3-dihydro-indol-2-one

HRID 2114878노트

반응식

HRID 2114878 반응식
[CH2:1]([N:3]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][C:10]=2[F:12])[C:5](=O)[C:4]1=[O:14])[CH3:2].O.NN>>[CH2:1]([N:3]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][C:10]=2[F:12])[CH2:5][C:4]1=[O:14])[CH3:2]

참가 물질

3

반응물 2

HCID 24654Hydrazine hydrate (1:1)HCID 692740961-Ethyl-7-fluoroindoline-2,3-dione

생성물 1

HCID 692741661-Ethyl-7-fluoro-1,3-dihydro-indol-2-one

실험 절차

1-Ethyl-7-fluoro-1H-indole-2,3-dione (3.60 g, 18.6 mmol) is heated with neat hydrazine hydrate (15 ml) at 130° C. for 60 minutes. The mixture is cooled, diluted with ice water and extracted with ethyl acetate. The extract is washed with brine, dried (Na2SO4), and evaporated to give the title compound as an orange solid. HPLC r.t. 4.60 min; MS for C10H10FNO m/z 198.1 (M+H)+.

후처리

  1. temperatureThe mixture is cooled
  2. extractionextracted with ethyl acetate
  3. washThe extract is washed with brine
  4. dry with materialdried (Na2SO4)
  5. customevaporated

출처 및 근거

ORD 기록
ord-874f48d9ff134c66b85b11ac059663fc
출처 데이터셋
uspto-grants-2008_10
특허 번호
US07435751B2

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