7-Fluoro-1-(2-fluoroethyl)indoline-2,3-dione → 7-Fluoro-1-(2-fluoro-ethyl)-1,3-dihydro-indol-2-one

HRID 2114885노트

반응식

HRID 2114885 반응식
[F:1][C:2]1[CH:3]=[CH:4][CH:5]=[C:6]2[C:10]=1[N:9]([CH2:11][CH2:12][F:13])[C:8](=[O:14])[C:7]2=O>O.NN>[F:1][C:2]1[CH:3]=[CH:4][CH:5]=[C:6]2[C:10]=1[N:9]([CH2:11][CH2:12][F:13])[C:8](=[O:14])[CH2:7]2

참가 물질

3

반응물 1

HCID 739475787-Fluoro-1-(2-fluoroethyl)indoline-2,3-dione

생성물 1

HCID 739475797-Fluoro-1-(2-fluoro-ethyl)-1,3-dihydro-indol-2-one

시약·촉매·용매 1

HCID 24654Hydrazine hydrate (1:1)용매

실험 절차

7-Fluoro-1-(2-fluoro-ethyl)-1H-indole-2,3-dione (1.04 g, 4.92 mmol) is heated with neat hydrazine hydrate (10 ml) at 130° C. for 20 minutes. The mixture is cooled, diluted with ice water and extracted with ethyl acetate. The extract is washed with brine, dried (Na2SO4), and evaporated to give the title compound as a brown solid. HPLC r.t. 4.36 min; MS for C10H9F2NO m/z 198.1 (M+H)+.

후처리

  1. temperatureThe mixture is cooled
  2. extractionextracted with ethyl acetate
  3. washThe extract is washed with brine
  4. dry with materialdried (Na2SO4)
  5. customevaporated

출처 및 근거

ORD 기록
ord-5bfc516fcc2c46f9bdc26ad529cf186c
출처 데이터셋
uspto-grants-2008_10
특허 번호
US07435751B2

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