Trifluoroacetic acid → HCID 67520244, 화합물

HRID 2115864노트

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HRID 2115864 반응식
Cl[C:2]1[C:11]2[C:6](=[CH:7][C:8]([O:14][CH3:15])=[C:9]([O:12][CH3:13])[CH:10]=2)[N:5]=[CH:4][N:3]=1.[NH2:16][C:17]1[CH:18]=[C:19]2[C:24](=[CH:25][CH:26]=1)[C:23]([C:27]([O:29][CH3:30])=[O:28])=[CH:22][CH:21]=[CH:20]2.C(O)(C(F)(F)F)=O.[OH-].[Na+]>O.C(O)(C)C>[CH3:13][O:12][C:9]1[CH:10]=[C:11]2[C:6](=[CH:7][C:8]=1[O:14][CH3:15])[N:5]=[CH:4][N:3]=[C:2]2[NH:16][C:17]1[CH:18]=[C:19]2[C:24](=[CH:25][CH:26]=1)[C:23]([C:27]([O:29][CH3:30])=[O:28])=[CH:22][CH:21]=[CH:20]2

참가 물질

7

반응물 4

HCID 6422Trifluoroacetic acidHCID 14798Sodium HydroxideHCID 27693644-Chloro-6,7-dimethoxyquinazolineHCID 24823732Methyl 6-aminonaphthalene-1-carboxylate

생성물 1

HCID 67520244HCID 67520244, 화합물

시약·촉매·용매 2

HCID 962Water용매HCID 3776Isopropanol용매

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온도
90 °C

실험 절차

The following reagents were combined in a flask and placed in a RT oil bath that was then heated to 90° C.: 4-Chloro-6,7-dimethoxyquinazoline (954 mg, 4.24 mmol), methyl 6-amino-1-naphthoate (857 mg, 4.24 mmol), TFA (098 mL, 12.7 mmol), and isopropanol (12 mL). The reaction was done before the bath reached the desired temperature. The mixture was diluted with water and made pH basic with 6N NaOH. The solid was filtered and rinsed with water and Et2O. The title compound was obtained as a pink solid.

후처리

  1. customThe following reagents were combined in a flask
  2. customplaced in a RT
  3. filtrationThe solid was filtered
  4. washrinsed with water and Et2O

출처 및 근거

ORD 기록
ord-fc5c3f77733e401896d0560eaff66790
출처 데이터셋
uspto-grants-2008_10
특허 번호
US07435823B2

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