Mesitylene → 2-Allyl-6-bromo-3-fluorophenol

반응식

C([O:4][C:5]1[CH:10]=[C:9]([F:11])[CH:8]=[CH:7][C:6]=1[Br:12])C=C.[C:13]1(C)[CH:18]=C(C)C=C(C)[CH:14]=1>>[CH2:18]([C:10]1[C:9]([F:11])=[CH:8][CH:7]=[C:6]([Br:12])[C:5]=1[OH:4])[CH:13]=[CH2:14]

참가 물질

반응물 2

HCID 7947Mesitylene

HCID 666546401-Bromo-2-allyloxy-4-fluorobenzene

생성물 1

HCID 689625392-Allyl-6-bromo-3-fluorophenol수율 95%

실험 절차

Treatment of 2-(allyloxy)-1-bromo-4-fluorobenzene (12.00 g, 0.052 mol) in refluxing mesitylene generally according to the reaction procedure described for Intermediate 8 provided 11.5 g (95%) of 2-allyl-6-bromo-3-fluorophenol as a pale yellow oil. Rf=0.48 (silica, ethyl acetate:hexanes 1:4); Anal. calcd. for C9H8BrFO: C, 46.78; H, 3.49. Found: C, 47.59; H, 3.47.

후처리

customgenerally according to the reaction procedure

출처 및 근거

ORD 기록: ord-d8946032437a4924a592cac15c85b8f9
출처 데이터셋: uspto-grants-2008_10
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07435837B2

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