Hydrochloric Acid → (4-Methoxycarbonylphenyl)-(3-hydroxypyridin-4-yl)-methanol hydrochloride

HRID 2116489노트

반응식

HRID 2116489 반응식
[CH3:1][O:2][C:3]([C:5]1[CH:10]=[CH:9][C:8]([CH:11]([C:13]2[CH:18]=[CH:17][N:16]=[CH:15][C:14]=2[O:19]COC)[OH:12])=[CH:7][CH:6]=1)=[O:4].[ClH:23]>CO>[ClH:23].[CH3:1][O:2][C:3]([C:5]1[CH:6]=[CH:7][C:8]([CH:11]([C:13]2[CH:18]=[CH:17][N:16]=[CH:15][C:14]=2[OH:19])[OH:12])=[CH:9][CH:10]=1)=[O:4]

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 69220240(4-Methoxycarbonylphenyl)-[3-(methoxymethoxy)pyridin-4-yl]-methanol

생성물 1

HCID 23103650(4-Methoxycarbonylphenyl)-(3-hydroxypyridin-4-yl)-methanol hydrochloride수율 81%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

Next, a mixture of (4-methoxycarbonylphenyl)-[3-(methoxymethoxy)pyridin-4-yl]-methanol (2.06 g, 6.79 mmol), methanol (35 mL) and concentrated hydrochloric acid (4.4 mL) was heated under reflux for 20 minutes. After cooling to room temperature, the reaction mixture was concentrated. Methanol and ethyl acetate were added to the residue and the resulting precipitate was filtered to give (4-methoxycarbonylphenyl)-(3-hydroxypyridin-4-yl)-methanol hydrochloride (1.87 g, 81%).

후처리

  1. temperaturewas heated
  2. temperatureunder reflux for 20 minutes
  3. concentrationthe reaction mixture was concentrated
  4. additionMethanol and ethyl acetate were added to the residue
  5. filtrationthe resulting precipitate was filtered

출처 및 근거

ORD 기록
ord-7ac00c7dfd4f4115be1636b672730a99
출처 데이터셋
uspto-grants-2008_10
특허 번호
US07439232B2

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