2-Amino-6-chlorobenzaldehyde → (+/-)-(2-Amino-6-chlorophenyl)-cyclopentyl-methanol

HRID 2117279

반응식

HRID 2117279 반응식
[NH2:1][C:2]1[CH:9]=[CH:8][CH:7]=[C:6]([Cl:10])[C:3]=1[CH:4]=[O:5].[CH:11]1([Mg]Br)[CH2:15][CH2:14][CH2:13][CH2:12]1>C(OCC)(=O)C>[NH2:1][C:2]1[CH:9]=[CH:8][CH:7]=[C:6]([Cl:10])[C:3]=1[CH:4]([CH:11]1[CH2:15][CH2:14][CH2:13][CH2:12]1)[OH:5]

참가 물질

4

반응물 2

HCID 223995122-Amino-6-chlorobenzaldehydeHCID 178419650HCID 178419650, 화합물

생성물 1

HCID 69315836(+/-)-(2-Amino-6-chlorophenyl)-cyclopentyl-methanol수율 36%

시약·촉매·용매 1

HCID 8857Ethyl Acetate용매

실험 절차

This compound was prepared using General Method 1 (EXAMPLE 1) from 2-amino-6-chlorobenzaldehyde (0.30 g, 1.9 mmol) and cyclopentylmagnesium bromide (2 M in ether, 1.9 mL)) to afford 0.16 g (36%) of (±)-(2-amino-6-chlorophenyl)-cyclopentyl-methanol after flash chromatography (4:1 hexanes:ethyl acetate).

후처리

  1. customThis compound was prepared

출처 및 근거

ORD 기록
ord-ada438d7963c4adbb6c39fe67aac7a39
출처 데이터셋
uspto-grants-2008_10
특허 번호
US07442696B2

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