Hexane → 1-Benzothien-7-ylboronic acid
반응식
Br[C:2]1[C:10]2[S:9][CH:8]=[CH:7][C:6]=2[CH:5]=[CH:4][CH:3]=1.C([Li])CCC.CCCCCC.[B:22](OC)([O:25]C)[O:23]C>CCOCC>[S:9]1[C:10]2[C:2]([B:22]([OH:25])[OH:23])=[CH:3][CH:4]=[CH:5][C:6]=2[CH:7]=[CH:8]1참가 물질
6
반응 조건
- 온도
- -10 °C
실험 절차
A solution of 7-bromo-1-benzothiophene (19.9 g, 0.094 mol) in absolute ether (200 ml) was treated with a 1.6 M solution of n-butyllithium in hexane (0.14 mol, 88 ml) at −78° C. The solution was stiffed at −78° C. for 10 minutes then treated with trimethyl borate (15 ml, 0.14 mol). The mixture was allowed to warm to −10° C. then quenched with an excess of dilute hydrochloric acid. The organic layer was separated, dried, evaporated, and the residue was recrystallised from aqueous ethanol to yield the title compound (10 g, 60%).
후처리
- customthen quenched with an excess of dilute hydrochloric acid
- customThe organic layer was separated
- customdried
- customevaporated
- customthe residue was recrystallised from aqueous ethanol
출처 및 근거
- ORD 기록
- ord-ece564e6cbef422489e0a200676991f5
- 출처 데이터셋
- uspto-grants-2008_10
- 특허 번호
- US07442701B2
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