Hydrochloric Acid → Methyl 3-(3-(aminomethyl)phenyl)propanoate hydrochloride

HRID 2117615

반응식

HRID 2117615 반응식
[CH3:1][O:2][C:3](=[O:14])[CH:4]=[CH:5][C:6]1[CH:11]=[CH:10][CH:9]=[C:8]([C:12]#[N:13])[CH:7]=1.[ClH:15]>[Pd].CO>[ClH:15].[CH3:1][O:2][C:3](=[O:14])[CH2:4][CH2:5][C:6]1[CH:11]=[CH:10][CH:9]=[C:8]([CH2:12][NH2:13])[CH:7]=1

참가 물질

5

반응물 2

HCID 313Hydrochloric AcidHCID 53396017Methyl 3-(3-cyanophenyl)prop-2-enoate

생성물 1

HCID 22282736Methyl 3-(3-(aminomethyl)phenyl)propanoate hydrochloride

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 887Methanol용매

실험 절차

A mixture of 3-(3-cyano-phenyl)-acrylic acid methyl ester of Step B (1.37 g, 7.32 mmol), 10% palladium on carbon (1.0 g), and HCl (4N in dioxane, 3 mL) in MeOH (50 mL) was hydrogenated on a Parr shaker at 50 psi for 65 h. The catalyst was removed by filtration through Celite and the solution was concentrated to provide the title compound (1.97 g). 1H NMR (400 MHz, CD3OD) δ 7.35-7.24 (m, 4H), 4.06 (s, 2H), 3.60 (s, 3H), 2.92 (t, 2H), 2.64 (t, 2H).

후처리

  1. customThe catalyst was removed by filtration through Celite
  2. concentrationthe solution was concentrated

출처 및 근거

ORD 기록
ord-52363373f5684974981a0b5e4625e536
출처 데이터셋
uspto-grants-2008_10
특허 번호
US07442702B2

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