Carbonic Acid → HCID 21914754, 화합물

HRID 2117842노트

반응식

HRID 2117842 반응식
[NH2:1][C:2]1[S:3][CH:4]=[C:5]([C:7]([O:9][CH2:10][CH3:11])=[O:8])[N:6]=1.N1C=CC=CC=1.[C:18](Cl)(=[O:22])[CH:19]([CH3:21])[CH3:20].C(=O)(O)O>ClCCl>[C:18]([NH:1][C:2]1[S:3][CH:4]=[C:5]([C:7]([O:9][CH2:10][CH3:11])=[O:8])[N:6]=1)(=[O:22])[CH:19]([CH3:21])[CH3:20]

참가 물질

6

반응물 4

HCID 767Carbonic AcidHCID 1049PyridineHCID 62325Isobutyryl chlorideHCID 73216Ethyl 2-aminothiazole-4-carboxylate

생성물 1

HCID 21914754HCID 21914754, 화합물

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

To an ice-cold mixture of ethyl 2-amino-1,3-thiazole-4-carboxylate (2 g) prepared in a similar manner according to Step 1 of the following Production Example 7, pyridine (1.3 ml) and dichloromethane (20 ml) was added isobutyryl chloride (0.91 ml) and stirred for 30 minutes. To the mixture was added saturated aqueous hydrogen bicarbonate (30 ml), and the organic layer was separated, dried over sodium sulfate and concentrated in vacuo. The crystalline residue was collected and washed with ethyl acetate to give ethyl 2-(isobutyrylamino)-1,3-thiazole-4-carboxylate (1.34 g).

후처리

  1. customprepared in a similar manner
  2. customthe organic layer was separated
  3. dry with materialdried over sodium sulfate
  4. concentrationconcentrated in vacuo
  5. customThe crystalline residue was collected
  6. washwashed with ethyl acetate

출처 및 근거

ORD 기록
ord-f44268f8cc2743baab84657a75522900
출처 데이터셋
uspto-grants-2008_10
특허 번호
US07442715B2

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