Hydrochloric Acid → 2-(acetylamino)-N-(4-aminophenyl)-1,3-thiazole-4-carboxamide hydrochloride

HRID 2117851노트

반응식

HRID 2117851 반응식
[C:1]([NH:4][C:5]1[S:6][CH:7]=[C:8]([C:10]([NH:12][C:13]2[CH:18]=[CH:17][C:16]([NH:19]C(=O)OC(C)(C)C)=[CH:15][CH:14]=2)=[O:11])[N:9]=1)(=[O:3])[CH3:2].[ClH:27]>CO.C(OCC)(=O)C>[ClH:27].[C:1]([NH:4][C:5]1[S:6][CH:7]=[C:8]([C:10]([NH:12][C:13]2[CH:18]=[CH:17][C:16]([NH2:19])=[CH:15][CH:14]=2)=[O:11])[N:9]=1)(=[O:3])[CH3:2]

참가 물질

5

반응물 2

HCID 313Hydrochloric AcidHCID 21915112Tert-butyl 4-({[2-(acetylamino)-1,3-thiazol-4-yl]carbonyl)amino}phenylcarbamate

생성물 1

HCID 219152912-(acetylamino)-N-(4-aminophenyl)-1,3-thiazole-4-carboxamide hydrochloride

시약·촉매·용매 2

HCID 887Methanol용매HCID 8857Ethyl Acetate용매

실험 절차

To a solution of tert-butyl 4-({[2-(acetylamino)-1,3-thiazol-4-yl]carbonyl)amino}phenylcarbamate (85 mg) in methanol (1 ml) was added 4N hydrogen chloride in ethyl acetate (1 ml), and the mixture was stirred at ambient temperature for 1 hour. The reaction mixture was concentrated in vacuo. The solid residue was collected and washed with ethyl acetate to give 2-(acetylamino)-N-(4-aminophenyl)-1,3-thiazole-4-carboxamide hydrochloride (70 mg).

후처리

  1. concentrationThe reaction mixture was concentrated in vacuo
  2. customThe solid residue was collected
  3. washwashed with ethyl acetate

출처 및 근거

ORD 기록
ord-8bacd9af2b784e1cb29002fb0e35a66f
출처 데이터셋
uspto-grants-2008_10
특허 번호
US07442715B2

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