Chloroacetyl chloride → N-[2-[4-(2-CHLOROACETYL)PHENYL]ETHYL]ACETAMIDE

HRID 2117858노트

반응식

HRID 2117858 반응식
[Cl-].[Al+3].[Cl-].[Cl-].[Cl:5][CH2:6][C:7](Cl)=[O:8].[C:10]1([CH2:16][CH2:17][NH:18][C:19](=[O:21])[CH3:20])[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1>ClCCCl>[Cl:5][CH2:6][C:7]([C:13]1[CH:14]=[CH:15][C:10]([CH2:16][CH2:17][NH:18][C:19](=[O:21])[CH3:20])=[CH:11][CH:12]=1)=[O:8]

참가 물질

5

반응물 3

HCID 6577Chloroacetyl chlorideHCID 70143N-(2-phenylethyl)acetamideHCID 6451240Aluminum(III) Chloride

생성물 1

HCID 2468242N-[2-[4-(2-CHLOROACETYL)PHENYL]ETHYL]ACETAMIDE수율 80.4%

시약·촉매·용매 1

HCID 111,2-Dichloroethane용매2회

실험 절차

Aluminium chloride (1.63 g) was dissolved in 1,2-dichloroethane (15 mL). Chloroacetylchloride (0.732 mL) was added to the mixture at 0° C., and stirred additionally for 20 minutes, then N-(2-phenylethyl)acetamide (1 g) in 1,2-dichloroethane (5 mL) was added dropwise. The mixture was stirred for 1 hour at room temperature, and then poured into ice water. The mixture was extracted with chloroform, washed with water and saturated sodium chloride solution, dried over sodium sulfate and concentrated in vacuo. The solid was washed with ethyl acetate and ethyl ether, and dried in vacuo to give N-{2-[4-(2-chloroacetyl)phenyl]ethyl}-acetamide as a white powder (1.18 g, 80.4%).

후처리

  1. stirringThe mixture was stirred for 1 hour at room temperature
  2. extractionThe mixture was extracted with chloroform
  3. washwashed with water and saturated sodium chloride solution
  4. dry with materialdried over sodium sulfate
  5. concentrationconcentrated in vacuo
  6. washThe solid was washed with ethyl acetate and ethyl ether
  7. customdried in vacuo

출처 및 근거

ORD 기록
ord-325f8e74e8ab49e8be732b0dbd7d3699
출처 데이터셋
uspto-grants-2008_10
특허 번호
US07442715B2

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