Hydrochloric Acid → Fasudil Hydrochloride

HRID 2118500

반응식

HRID 2118500 반응식
[CH:1]1[C:10]2[CH:9]=[CH:8][CH:7]=[C:6]([S:11]([N:14]3[CH2:20][CH2:19][CH2:18][NH:17][CH2:16][CH2:15]3)(=[O:13])=[O:12])[C:5]=2[CH:4]=[CH:3][N:2]=1.[ClH:21]>CO>[ClH:21].[CH:1]1[C:10]2[CH:9]=[CH:8][CH:7]=[C:6]([S:11]([N:14]3[CH2:20][CH2:19][CH2:18][NH:17][CH2:16][CH2:15]3)(=[O:12])=[O:13])[C:5]=2[CH:4]=[CH:3][N:2]=1

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 3547Fasudil

생성물 1

HCID 163751Fasudil Hydrochloride

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

5 g of 1-(5-isoquinolinesulfonyl)homopiperazine (Compound(1)) as prepared in substantially the same manner as in Example 3 was dissolved in 40 ml of methanol, and the pH of the solution was adjusted to 6 with 1N hydrochloric acid. Then the solution was condensed under reduced pressure to obtain a crystalline residue. The crystalline residue thus obtained was recrystallized from methanol-ether to obtain 1-(5isoquinolinesulfonyl)homopiperazine hydrochloride. Analytical data on this compound are given below.

후처리

  1. customcondensed under reduced pressure
  2. customto obtain a crystalline residue
  3. customThe crystalline residue thus obtained
  4. customwas recrystallized from methanol-ether

출처 및 근거

ORD 기록
ord-c475e692aaaf4926b344fed11d73eb97
출처 데이터셋
uspto-grants-1987_07
특허 번호
US04678783

연결된 노트

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