Sodium Chloride → Arecoline

HRID 2118631노트

반응식

HRID 2118631 반응식
[CH3:1][N:2]1[CH2:7][C:6]([C:8]([O:10][CH3:11])=[O:9])=[CH:5][CH2:4][CH2:3]1.Br.[OH-].[K+].[Na+].[Cl-]>O>[CH3:1][N:2]1[CH2:7][C:6]([C:8]([O:10][CH3:11])=[O:9])=[CH:5][CH2:4][CH2:3]1

참가 물질

5

반응물 3

HCID 5234Sodium ChlorideHCID 9301Arecoline HydrobromideHCID 14797Potassium Hydroxide

생성물 1

HCID 2230Arecoline

시약·촉매·용매 1

HCID 962Water용매

실험 절차

Ten grams of arecoline HBr was dissolved in a minimal quantity (approximately 25 ml) of water and adjusted to pH 10 with saturated KOH in a separatory funnel. One hundred mls of petroleum ether was added and the layers were mixed. NaCl was then added to saturate the aqueous layer. The organic layer was collected, and the aqueous layer was extracted three more times with petroleum ether. The combined organic layers were transferred to a 500 ml round bottom flask, boiling chips were added and the petroleum ether was removed by distillation. The remaining oil was layered with N2 and stored in low-actinic glassware. The oil was anlyzed by NMR to show the absence of a halogen component.

후처리

  1. additionthe layers were mixed
  2. concentrationto saturate the aqueous layer
  3. customThe organic layer was collected
  4. extractionthe aqueous layer was extracted three more times with petroleum ether
  5. customThe combined organic layers were transferred to a 500 ml round bottom flask
  6. additionwere added
  7. customthe petroleum ether was removed by distillation

출처 및 근거

ORD 기록
ord-57bbea72f6b5493f9057fa013e751251
출처 데이터셋
uspto-grants-1987_07
특허 번호
US04680172

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