Hydrazine hydrate (1:1) → 1-Amino-8-(1-naphthyloxy)octane

HRID 2118659노트

반응식

HRID 2118659 반응식
[C:1]1([O:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][N:20]2C(=O)C3=CC=CC=C3C2=O)[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][CH:2]=1.O.NN>C(O)C>[NH2:20][CH2:19][CH2:18][CH2:17][CH2:16][CH2:15][CH2:14][CH2:13][CH2:12][O:11][C:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][CH:2]=1

참가 물질

4

반응물 2

HCID 24654Hydrazine hydrate (1:1)HCID 13520543N-8-(1-naphthyloxy)octylphthalimide

생성물 1

HCID 135205411-Amino-8-(1-naphthyloxy)octane

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

A solution of 10.0 g N-[8-(1-naphthyloxy)octyl]phthalimide, prepared as above, and 200 ml of ethanol and 3.2 ml of hydrazine hydrate was refluxed for 18 hours. The solution was evaporated to about 100 ml, and diluted with 200 ml of water, then basified with aqueous potassium hydroxide and extracted with hexane. The extract was washed, dried and evaporated to give the title compound as an oil which was converted to the hydrochloride, mp 90.5°-92°.

후처리

  1. temperaturewas refluxed for 18 hours
  2. customThe solution was evaporated to about 100 ml
  3. additiondiluted with 200 ml of water
  4. extractionextracted with hexane
  5. washThe extract was washed
  6. customdried
  7. customevaporated

출처 및 근거

ORD 기록
ord-8730f934c84d41ea84f6537e8950a6b8
출처 데이터셋
uspto-grants-1987_07
특허 번호
US04680300

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