7-Amino-4-vinylisoindolinone → 7-Amino-4-ethylisoindolinone

HRID 21187

반응식

HRID 21187 반응식
[NH2:1][C:2]1[CH:3]=[CH:4][C:5]([CH:12]=[CH2:13])=[C:6]2[C:10]=1[C:9](=[O:11])[NH:8][CH2:7]2.[H][H]>CN(C=O)C.[Pd]>[NH2:1][C:2]1[CH:3]=[CH:4][C:5]([CH2:12][CH3:13])=[C:6]2[C:10]=1[C:9](=[O:11])[NH:8][CH2:7]2

참가 물질

5

반응물 2

HCID 684886597-Amino-4-vinylisoindolinoneHCID 178418361HCID 178418361, 화합물

생성물 1

HCID 684909697-Amino-4-ethylisoindolinone수율 102.8%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 6228Dimethylformamide용매

실험 절차

7-Amino-4-vinylisoindolinone (50.0 mg, 0.287 mmol) was dissolved in DMF (2.5 mL), and the solution was added with 10% Pd—C (10 mg) followed by stirring at room temperature for 1.8 hours under normal pressure and hydrogen atmosphere. The reaction mixture was filtered using Celite and the solvent of the filtrate was evaporated under reduced pressure to obtain 7-amino-4-ethylisoindolinone (52.0 mg, quantitative).

후처리

  1. filtrationThe reaction mixture was filtered
  2. customthe solvent of the filtrate was evaporated under reduced pressure

출처 및 근거

ORD 기록
ord-9b574fe409a9418d963834a7bf341de1
출처 데이터셋
uspto-grants-2010_06
특허 번호
US07745641B2

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