7-Amino-4-vinylisoindolinone → 7-Amino-4-ethylisoindolinone
반응식
[NH2:1][C:2]1[CH:3]=[CH:4][C:5]([CH:12]=[CH2:13])=[C:6]2[C:10]=1[C:9](=[O:11])[NH:8][CH2:7]2.[H][H]>CN(C=O)C.[Pd]>[NH2:1][C:2]1[CH:3]=[CH:4][C:5]([CH2:12][CH3:13])=[C:6]2[C:10]=1[C:9](=[O:11])[NH:8][CH2:7]2참가 물질
5
실험 절차
7-Amino-4-vinylisoindolinone (50.0 mg, 0.287 mmol) was dissolved in DMF (2.5 mL), and the solution was added with 10% Pd—C (10 mg) followed by stirring at room temperature for 1.8 hours under normal pressure and hydrogen atmosphere. The reaction mixture was filtered using Celite and the solvent of the filtrate was evaporated under reduced pressure to obtain 7-amino-4-ethylisoindolinone (52.0 mg, quantitative).
후처리
- filtrationThe reaction mixture was filtered
- customthe solvent of the filtrate was evaporated under reduced pressure
출처 및 근거
- ORD 기록
- ord-9b574fe409a9418d963834a7bf341de1
- 출처 데이터셋
- uspto-grants-2010_06
- 특허 번호
- US07745641B2
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