반응식
Br[C:2]1(OC)[CH2:11][CH2:10][C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[O:3]1.C([Li])CCC.CN(C)[CH:21]=[O:22].C[CH2:25][O:26]CC>C(OC(C)C)(C)C>[CH3:25][O:26][C:5]1[CH:6]=[C:7]([CH:21]=[O:22])[CH:8]=[C:9]2[C:4]=1[O:3][CH2:2][CH2:11][CH2:10]2참가 물질
6
반응 조건
- 온도
- -50 °C
실험 절차
The procedure is as according to the method described for preparation III, but maintaining the temperature at -50° C. From 186 g (7.7×10-1M) of bromo-methoxy-chroman Ib2 in 500 cm3 of anhydrous ether and 7.7×10-1M of n-butyllithium in 650 cm3 of anhydrous ether, and after addition of 78 g (1.1M) of N,N-dimethylformamide in 200 cm3 of anhydrous ether and recrystallisation in isopropyl ether, 75 g (yield=51%) of expected compound are isolated.
출처 및 근거
- ORD 기록
- ord-7bd04b9411524ac1a93fde216abe0d4a
- 출처 데이터셋
- uspto-grants-1987_07
- 특허 번호
- US04680411
연결된 노트
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