Bromine → 4-Bromo-3-(4-chlorophenyl)-2,2-dimethylcyclobutan-1-one

HRID 2119059노트

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HRID 2119059 반응식
[CH3:1][C:2]1([CH3:14])[CH:5]([C:6]2[CH:11]=[CH:10][C:9]([Cl:12])=[CH:8][CH:7]=2)[CH2:4][C:3]1=[O:13].[Br:15]Br>C(Cl)(Cl)Cl>[CH3:1][C:2]1([CH3:14])[CH:5]([C:6]2[CH:7]=[CH:8][C:9]([Cl:12])=[CH:10][CH:11]=2)[CH:4]([Br:15])[C:3]1=[O:13]

참가 물질

4

반응물 2

HCID 24408BromineHCID 11789026Cyclobutanone, 3-(4-chlorophenyl)-2,2-dimethyl-

생성물 1

HCID 132771724-Bromo-3-(4-chlorophenyl)-2,2-dimethylcyclobutan-1-one수율 90.4%

시약·촉매·용매 1

HCID 6212Chloroform용매2회

반응 조건

온도
20 °C

실험 절차

2.08 g (0.01 mol) of 2,2-dimethyl-3-(4-chlorophenyl)cyclobutanone are dissolved in 30 ml of chloroform, and a solution of 1.6 g of bromine in 5 ml of chloroform is added dropwise. After stirring for one hour at 20° C., the solvent is distilled off under waterpump vacuum. 2.6 g of crude 2,2-dimethyl-3-(4-chlorophenyl)-4-bromocyclobutanone are obtained as a residue which is employed further without further purification (compare: Example 1).

후처리

  1. distillationthe solvent is distilled off under waterpump vacuum

출처 및 근거

ORD 기록
ord-ba5eb40b33b04962a57082208a8dc68a
출처 데이터셋
uspto-grants-1987_07
특허 번호
US04681952

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