Hydrochloric Acid → HCID 15839202, 화합물

HRID 2119427노트

반응식

HRID 2119427 반응식
[OH:1][CH:2]([C:5]([C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1)([C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1)[CH3:6])[C:3]#[N:4].Cl.C[OH:21]>>[OH:1][CH:2]([C:5]([C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1)([C:7]1[CH:8]=[CH:9][CH:10]=[CH:11][CH:12]=1)[CH3:6])[C:3]([NH2:4])=[O:21]

참가 물질

4

반응물 3

HCID 313Hydrochloric Acid2회HCID 887MethanolHCID 15839203HCID 15839203, 화합물

생성물 1

HCID 15839202HCID 15839202, 화합물

반응 조건

온도
5 °C

실험 절차

10.0 g (4.22 [sic] mmol) of 2-hydroxy-3,3-diphenylbutyronitrile were dissolved in 500 ml of methanol (abs.) and, at 5-10° C., HCl was passed in for 3 hours. The mixture was then stirred at 5° C. for 3 hours and at room temperature for 16 hours. Then 200 ml of 6 molar HCl were added and the mixture was evaporated to dryness under reduced pressure. The crude product was recrystallized from an ethyl acetate/heptane mixture. 2.5 g (23%) of 2-hydroxy-3,3-dihenylbutyramide were obtained as a white solid.

후처리

  1. customwas passed in for 3 hours
  2. customthe mixture was evaporated to dryness under reduced pressure
  3. customThe crude product was recrystallized from an ethyl acetate/heptane mixture
  4. custom2.5 g (23%) of 2-hydroxy-3,3-dihenylbutyramide were obtained as a white solid

출처 및 근거

ORD 기록
ord-4c7251aad4f4428698522ffb509a9230
출처 데이터셋
uspto-grants-2004_02
특허 번호
US06686369B1

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