Hydrochloric Acid → [2-(3-Amino-propylamino)-thiazol-5-yl]-o-tolyl-methanone

HRID 2119606노트

반응식

HRID 2119606 반응식
C(OC(=O)[NH:7][CH2:8][CH2:9][CH2:10][NH:11][C:12]1[S:13][C:14]([C:17](=[O:25])[C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][C:19]=2[CH3:24])=[CH:15][N:16]=1)(C)(C)C.Cl.C(=O)(O)[O-].[Na+]>O1CCOCC1>[NH2:7][CH2:8][CH2:9][CH2:10][NH:11][C:12]1[S:13][C:14]([C:17]([C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][C:19]=2[CH3:24])=[O:25])=[CH:15][N:16]=1

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 516892Sodium BicarbonateHCID 20616905{3-[5-(2-Methyl-benzoyl)-thiazol-2-ylamino]-propyl}-carbamic Acid tert-butyl Ester

생성물 1

HCID 23442548[2-(3-Amino-propylamino)-thiazol-5-yl]-o-tolyl-methanone수율 102.2%

시약·촉매·용매 1

HCID 312751,4-Dioxane용매

실험 절차

339 mg {3-[5-(2-Methyl-benzoyl)-thiazol-2-ylamino]-propyl}-carbamic acid tert-butyl ester was added to a solution of 25% aqueous hydrochloric acid in dioxane. The mixture was stirred 1 h at room temperature and maintained overnight in the refrigerator. The mixture was poured into saturated aqueous sodium bicarbonate solution (50 ml). The organics were extracted with dichloromethane (3×50 ml), dried over magnesium sulfate and evaporated under reduced pressure to afford the title compound as yellow foam (254 mg) which was used without further purification.

후처리

  1. temperaturemaintained overnight in the refrigerator
  2. extractionThe organics were extracted with dichloromethane (3×50 ml)
  3. dry with materialdried over magnesium sulfate
  4. customevaporated under reduced pressure

출처 및 근거

ORD 기록
ord-e5002b6f0d2f4f38949d84439ff9188f
출처 데이터셋
uspto-grants-2004_02
특허 번호
US06686381B2

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