Acetic Acid → 7-Benzyl-1-methyl-1,4-dihydro-pyrazolo[4,3-b]quinolin-9-one

HRID 2119626

반응식

HRID 2119626 반응식
[CH2:1]([C:8]1[CH:17]=[CH:16][C:15]2[N:14]=[C:13]3[CH:18]=[N:19][N:20]([CH3:21])[C:12]3=[C:11](Cl)[C:10]=2[CH:9]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.C(O)(=[O:25])C>>[CH2:1]([C:8]1[CH:17]=[CH:16][C:15]2[NH:14][C:13]3[CH:18]=[N:19][N:20]([CH3:21])[C:12]=3[C:11](=[O:25])[C:10]=2[CH:9]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

참가 물질

3

반응물 2

HCID 176Acetic AcidHCID 234423817-benzyl-9-chloro-1-methyl-1H-pyrazolo[4,3-b]quinoline

생성물 1

HCID 98571507-Benzyl-1-methyl-1,4-dihydro-pyrazolo[4,3-b]quinolin-9-one수율 96%

실험 절차

A mixture of 7-benzyl-9-chloro-1-methyl-1H-pyrazolo[4,3-b]quinoline (EXAMPLE 11, step 2, 1.00 g, 3.25 mmol) in 50% aqueous acetic acid (20 ml) was refluxed for 6 h. After cooling to room temperature, the formed solid was collected by filtration to give 905 mg (96%) of the title compound as a white solid.

후처리

  1. temperaturewas refluxed for 6 h
  2. filtrationthe formed solid was collected by filtration

출처 및 근거

ORD 기록
ord-29f4e4f88cb142d39c248e59a02d885a
출처 데이터셋
uspto-grants-2004_02
특허 번호
US06686373B2

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