Cytarabine → Acetamide, N-(1-beta-D-arabinofuranosyl-1,2-dihydro-2-oxo-4-pyrimidinyl)-

HRID 2119775노트

반응식

HRID 2119775 반응식
[C@@H:1]1([N:10]2[CH:17]=[CH:16][C:14]([NH2:15])=[N:13][C:11]2=[O:12])[O:7][C@H:6]([CH2:8][OH:9])[C@@H:4]([OH:5])[C@@H:2]1[OH:3].[C:18](OC(=O)C)(=[O:20])[CH3:19]>>[C@@H:1]1([N:10]2[CH:17]=[CH:16][C:14]([NH:15][C:18](=[O:20])[CH3:19])=[N:13][C:11]2=[O:12])[O:7][C@H:6]([CH2:8][OH:9])[C@@H:4]([OH:5])[C@@H:2]1[OH:3]

참가 물질

3

반응물 2

HCID 6253CytarabineHCID 7918Acetic Anhydride

생성물 1

HCID 83533Acetamide, N-(1-beta-D-arabinofuranosyl-1,2-dihydro-2-oxo-4-pyrimidinyl)-

실험 절차

introducing an acyl group at the N4 position of 1-β-D-arabinofuranosyl cytosine with an acylating agent, for example using acetic anhydride under conditions suitable for obtaining 1-β-D-arabinofuranosyl-N4-acetyl cytosine,

출처 및 근거

ORD 기록
ord-53fcceddad424ae7b0be80c79fb32a1c
출처 데이터셋
uspto-grants-2004_02
특허 번호
US06686463B2

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