Acetic Anhydride → 5-Bromo-2-(5-methyl-1,3,4-oxadiazol-2-yl)pyridine

HRID 2120106노트

반응식

N1[C:5]([C:6]2[CH:11]=[CH:10][C:9]([Br:12])=[CH:8][N:7]=2)=[N:4][N:3]=N1.[C:13](OC(=O)C)(=[O:15])[CH3:14]>>[CH3:14][C:13]1[O:15][C:5]([C:6]2[CH:11]=[CH:10][C:9]([Br:12])=[CH:8][N:7]=2)=[N:4][N:3]=1

참가 물질

반응물 2

HCID 7918Acetic Anhydride

HCID 234386835-Bromo-2-(2H-tetrazol-5-yl)pyridine

생성물 1

HCID 234386435-Bromo-2-(5-methyl-1,3,4-oxadiazol-2-yl)pyridine

실험 절차

In 10 ml of acetic anhydride was dissolved 1 g of 2-(5-tetrazolyl)-5-bromopyridine, followed by refluxing for 2 hours. After completion of the reaction, the same post-treatment as in Preparation Example 13 was conducted to give the title compound. 0.6 g.

후처리

temperatureby refluxing for 2 hours
customAfter completion of the reaction
customthe same post-treatment as in Preparation Example 13

출처 및 근거

ORD 기록: ord-bae44cf0b4384f059428f5c6467c2335
출처 데이터셋: uspto-grants-2004_02
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US06689779B2

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